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I purchased a slingbox yesterday and could not complete the installation using IE 8 because the cursor turned into a plus sign and click functioning did not work, much the same as the original poster of this problem.
Then I used Firefox. I was able to install ok using Firefox, however, now when I try to use another instance of Firefox to do my regular browsing while watching slingbox, the mouse disappears. I have two monitors. If I bring my mouse back over the slingbox window, the mouse will reappear long enough for me to get my bearings and navigate in the other window again for a while, but within seconds, it will disappear again.
I just tried IE 8 again. I switched to compatibility view and my cursor appeared long enough to select my slingbox, then reverted to a plus sign again.
The instructions at Resetting the Watch on Slingbox.com plugins for Internet Explorer (ActiveX) and Firefox did not solve the problem.