I think I may be able to help you with your situation. This article is for the SOLO but it might be worth trying these steps anyway. Let me know if it helps! Do you see a line or distortion at the bottom of the SlingPlayer window when you stream from your Slingbox SOLO?
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When playing a THX Optimizer Video I noticed a few things. One, at times there is no indication of any problems (See Screen Shot 5), but compare that to Screen Shot 9 and the only difference is more use of color in the screen.
Also take a look at screen shot 7 and 8 - first see how the green box indicating the maximum screen area only shows one side, the bottom (on a dot-by-dot view on the tv you see a green box), also notice if you look at both shots in quick sucession you can see green line shimmer. This probably has to do with the copression, but it had similar qualities to the speckling in the other screen shots.
I can only guess it is related to the streaming compression. E.g. if I pause the video it seems to mostly go away. Also it almost looks like it's going beyond the edge of the picture by two pixels.
Take a look at the Side By Side image. The one on the left is from a pause image, the one on the right is take while the video is playing. They both have some speckling, but the paused image is much less visible. And it looks like it's goes out 2 pixels beyond the edge. Now on my computer screen it can't do full 1920x1080 so the image is scaled to 1680x942.
One last screen shot from a video playing back on a 1920x1080 screen, zoomed in so you can see the pixels. It looks like it has the same problem, it's looks like there are two pixels beneeth the picture that it's showing and the speckles are showing up in.
Maybe it's cutting off two pixels at the top and going two pixels past the end of the image at the bottom?
1080pZoom.png 15.3 K
In order to try and confirm that this wasn't just a problem with my setup I went looking for screen shots from other Sling 350 users. I wasn't able to find anyone who posted full resolution images yet, but found several reviews that seem to have the same problem.
Since the images are so small, you have to zoom in to really see it, but it has the same speckling and it extends two pixels below the screen.
When viewing at a full resolution ( >1920x1080) on a large monitor (say 24") it's blatantly obvious and quite distracting.